Lipid Intermediates in the Biosynthesis of Bacterial Peptidoglycan
نویسنده
چکیده
INTRODUCTION .......................................................................................................................................................620 DETECTION OF THE LIPID INTERMEDIATES IN CELL-FREE SYSTEMS ..............................................621 DETECTION OF THE LIPID INTERMEDIATES IN INTACT CELLS AND THEIR POOL LEVELS ......621 ISOLATION AND PURIFICATION OF THE LIPID INTERMEDIATES.........................................................621 STRUCTURE OF THE LIPID INTERMEDIATES...............................................................................................622 SYNTHESIS OF THE LIPID INTERMEDIATES AND ANALOGUES .............................................................623 BIOSYNTHESIS OF LIPID I ...................................................................................................................................623 BIOSYNTHESIS OF LIPID II..................................................................................................................................624 BIOSYNTHESIS OF MODIFIED LIPID INTERMEDIATES.............................................................................625 CELLULAR LOCATION OF THE LIPID INTERMEDIATES AND TRANSLOCATION OF LIPID II.........627 GLYCAN CHAIN FORMATION WITH LIPID II.................................................................................................628 COMPLEXES BETWEEN THE LIPID INTERMEDIATES AND ANTIBIOTICS...........................................629 CONCLUDING REMARKS......................................................................................................................................630 ACKNOWLEDGMENTS ...........................................................................................................................................631 REFERENCES ............................................................................................................................................................631
منابع مشابه
Lipid intermediates in the biosynthesis of bacterial peptidoglycan.
This review is an attempt to bring together and critically evaluate the now-abundant but dispersed data concerning the lipid intermediates of the biosynthesis of bacterial peptidoglycan. Lipid I, lipid II, and their modified forms play a key role not only as the specific link between the intracellular synthesis of the peptidoglycan monomer unit and the extracytoplasmic polymerization reactions ...
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